Protein Tyrosine Kinase Compound Library

Cat. No. : CS-L016 (959 compounds)
Library Contents: PDF | SDF

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 959 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Size (Pre-dissolved DMSO or Solid) Stock Price
30 μL/well (10 mM solution) In-stock Get quote
50 μL/well (10 mM solution) In-stock Get quote
100 μL/well (10 mM solution) In-stock Get quote
250 μL/well (10 mM solution) In-stock Get quote
Products are for research use only. Not for human use. We do not sell to patients.

Bulk Inquiry

Collapse
Your information is safe with us. * Required Fields
  Salutation:
* Country or Region:
* Applicant name:
* Organization Name:
* Email address:
* Requested quantity:
* Phone number:
  Remarks:
 
Please slide the slider!
>>
 
Name, 
Organization name, 
Email address, 
Requested quantity, 
Phone number, 

Request SDF File

x

Please enter your email address. We will send your requested SDF file to you as soon as possible.

  • Data Sheet

  • Description & Advantages

  • Composition

  • Contents

Formulation:A collection of 959 protein kinase inhibitors supplied as pre-dissolved Solutions or Solid
Container:96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:-80°C
Shipping:Blue ice

•   A unique collection of 959 protein kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as VEGFR, ALK, Btk, Bcr-Abl, c-Met/HGFR, EGFR, FGFR, Insulin Receptor, JAK, PDGFR, etc.

•   A useful tool for the research for PTK-related diseases, such as cancer.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some protein kinase inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active and cell permeable.

•   Rich documentation with structure, IC50 and summary.

•   NMR and HPLC to ensure the high purity.

•   All compounds are in stock and continuously updated.

PDF
Browsing History

    Customize Your Library

    You can select:
    • Specific Compounds
    • Quantities
    • Plate map
    • Concentration
    • Format (Solid or DMSO Solution)

    Please contact us at sales@chemscene.com

    Recommend Products
    CS-L139 Cat. No. : CS-L139

    (1711)

    Pain-Related Compound Library

    CS-L017 Cat. No. : CS-L017

    (1503 compounds)

    Stem Cell Signaling Compound Library

    CS-L124 Cat. No. : CS-L124

    (2093)

    Anti-Prostate Cancer Compound Library