Fragment Library

Cat. No. : CS-L032 (21965 compounds)
Library Contents: PDF | SDF

Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function; it can cover broad swaths of chemical space and allows the use of creative chemistry. Fragment-based drug discovery is well-established in industry and has resulted in a variety of drugs entering clinical trials, with two, vemurafenib and venetoclax, already approved. FBDD also has key attractions for academia. Notably, it is able to tackle difficult or novel targets for which no chemical matter may be found in existing HTS collections.

MCE designs a unique collection of 21965 fragment compounds, all of which obey a heuristic rule called the “Rule of Three (RO3) ”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This library is an important source of lead-like drugs.

Size (Pre-dissolved DMSO or Solid) Stock Price
50 μL/well (10 mM solution) In-stock Get quote
100 μL/well (10 mM solution) In-stock Get quote
Products are for research use only. Not for human use. We do not sell to patients.

Bulk Inquiry

Collapse
Your information is safe with us. * Required Fields
  Salutation:
* Country or Region:
* Applicant name:
* Organization Name:
* Email address:
* Requested quantity:
* Phone number:
  Remarks:
 
Please slide the slider!
>>
 
Name, 
Organization name, 
Email address, 
Requested quantity, 
Phone number, 

Request SDF File

x

Please enter your email address. We will send your requested SDF file to you as soon as possible.

  • Data Sheet

  • Description & Advantages

  • Composition

  • Contents

Formulation:A collection of 21965 fragment compounds supplied as pre-dissolved Solutions or Solid
Container:96- or 384-well Plate with Peelable Foil Seal
Storage:-80°C
Shipping:Blue ice

•   A unique collection of 21965 fragment compounds for traditional lead identification via high-throughput screening (HTS).

•   The compounds follow the Rule of Three.

•   A useful tool for the fragment-based approach to drug discovery (FBDD).

•   More detailed compound information with structure, Molecular Weight, cLogP, H-donor and H-acceptor number.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

Parameter Range Average Value
Molecular Weight ≤300 181.75
cLogP ≤3.0 1.6179
H-donors ≤3.0 2.07
H-acceptors ≤3.0 0.78

PDF
Browsing History

    Customize Your Library

    You can select:
    • Specific Compounds
    • Quantities
    • Plate map
    • Concentration
    • Format (Solid or DMSO Solution)

    Please contact us at sales@chemscene.com

    Recommend Products
    CS-L154 Cat. No. : CS-L154

    (2895)

    Cysteine Targeted Covalent Fragment Library

    CS-L097 Cat. No. : CS-L097

    (51 compounds)

    Animal Disease Model Inducer Library

    CS-L101 Cat. No. : CS-L101

    (1645 compounds)

    Anti-Liver Cancer Compound Library