Drug-Induced Liver Injury (DILI) Compound Library
Cat. No. : | CS-L076 | (1356 compounds) |
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Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug.
DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.
MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 1356 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.
Size (Pre-dissolved DMSO or Solid) | Stock | Price |
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30 μL/well (10 mM solution) | In-stock | Get quote |
50 μL/well (10 mM solution) | In-stock | Get quote |
100 μL/well (10 mM solution) | In-stock | Get quote |
250 μL/well (10 mM solution) | In-stock | Get quote |
Data Sheet
Description & Advantages
Composition
Contents
Formulation: | A collection of 1356 drug-induced liver injury compounds supplied as pre-dissolved Solutions or Solid |
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Container: | 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode |
Storage: | -80°C |
Shipping: | Blue ice |
Customize Your Library
You can select:- Specific Compounds
- Quantities
- Plate map
- Concentration
- Format (Solid or DMSO Solution)
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