Target Protein Ligand Library

Cat. No. : CS-L129 (38)
Library Contents: PDF | SDF

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 38 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

Size (Pre-dissolved DMSO or Solid) Stock Price
30 μL/well (10 mM solution) In-stock Get quote
50 μL/well (10 mM solution) In-stock Get quote
100 μL/well (10 mM solution) In-stock Get quote
250 μL/well (10 mM solution) In-stock Get quote
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  • Data Sheet

  • Description & Advantages

  • Composition

  • Contents

Formulation:A collection of 38 ligands for target proteins of PROTAC supplied as pre-dissolved Solutions or Solid.
Container:96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.
Storage:-80°C
Shipping:Blue ice

•   A unique collection of 38 ligands for target protein of PROTAC, which can be used for PROTAC design.

•   A useful tool for PROTAC development.

•   Mainly target AR, ER, BTK, BET, and BCR-ABL.

•   More detailed compound information with structure, IC50, and brief introduction.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

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